- Inositol+ — 120 vegetarian capsules (30-day supply). Myo-Inositol 2,000mg + D-Chiro Inositol 50mg in the researched 40:1 ratio, with Folate and Vitamin D.
- HCl & Phytosome Berberine — 60 vegetarian capsules (30-day supply). 450mg HimaBerb® Berberine HCl + 550mg Berberine Phytosome®.
- Both vegan, non-GMO, third-party tested and made in a GMP-certified U.S. facility
- Inositol+: 4 capsules daily with food and water (or split 2 morning, 2 evening)
- Berberine: 2 capsules daily with food. Sensitive stomach? Start with 1 capsule and build up
- They can be taken together at the same meal — no mixing, no measuring
- Consistency is key — give the routine a full 12 weeks before evaluating results
The Metabolic Duo: Inositol+ & Berberine, Together.
Trusted by 250K+ women · Read the reviewsMore balanced hormones, fewer cravings, steadier energy. This powerhouse duo supports healthy blood sugar and metabolic health while helping you feel more balanced from the inside out.*
- Supports hormonal balance, regular cycles and clearer skin*
- Supports healthy blood sugar, fewer cravings and steadier energy*
- Supports healthy weight management and metabolism*
Same system, two angles.
Insulin signaling goes beyond blood sugar, influencing the hormones behind your cycle, skin, cravings, mood and energy. Inositol+ supports it from the hormone side, while Berberine supports it from the metabolic side.*
Inositol+
2,000mg Myo-Inositol and 50mg D-Chiro Inositol in the researched 40:1 ratio, plus Folate and Vitamin D. Supports healthy insulin signaling inside the ovaries, balanced hormone production, regular ovulation and clearer skin.*
Dual Action Berberine
450mg of 97%-pure HimaBerb® Berberine HCl paired with 550mg of clinically studied Berberine Phytosome® — a 1,000mg dual-form serving that activates AMPK, your cells’ metabolic “master switch,” to support balanced blood sugar, fewer cravings and healthy weight management.*
Why Take Them Together?
When insulin signaling is off, it can show up everywhere — cycles, skin, cravings, energy and weight. Inositol+ and Berberine work on that same system from two directions, which is why so many women build their daily routine around both.*
Inositol+ works inside the cell
Myo- and D-Chiro Inositol act as insulin “second messengers,” helping cells respond to insulin and supporting balanced ovarian hormone production, ovulation and regular cycles.*
Berberine works on metabolism
Berberine activates AMPK, the enzyme that governs how your body uses glucose and fat — supporting healthy blood sugar already in a normal range, fewer sugar cravings and steadier energy.*
Together, one complete routine
Hormone support plus metabolic support, in two clinically studied formulas, delivered together every month for less than buying them separately.
Is the Duo Right for You?
Women who see the best results with both products usually recognize themselves in one of these.
Irregular or missing cycles
Your period is unpredictable, late, or sometimes doesn’t show up for months — and you want a natural daily routine to support regular ovulation.*
Cravings, energy dips & stubborn weight
You crash after meals, fight sugar cravings in the afternoon, and weight seems to hold on no matter what you do.*
Hormonal acne, hair & mood swings
Jawline breakouts, unwanted hair growth, or moods that swing with your cycle — the classic signs your hormones and insulin are out of sync.*
Building a natural routine
You’d rather support your body with clinically studied nutrients than add another prescription — and you want a plan you can stick with.*
If you have a diagnosed condition or take medication, talk with your healthcare provider before starting any new supplement.
Restore Your Rhythm
What to expect, month by month.
- 1
Month 1
Fewer sugar cravings and steadier post-meal energy from Berberine, with early improvements in energy and mood as Inositol+ builds up.*
- 2
Month 2
More consistent daily energy and appetite as both formulas support healthy insulin signaling and metabolism.*
- 3
Month 3
Cycle and skin improvements are typically noticed by weeks 8–12 of consistent Inositol+ use, alongside sustained metabolic balance.*
- 4+
Month 4+
Long-term hormonal and metabolic support as a daily habit — the routine most women stay on.*
Inositol+ works with your body’s natural systems to support insulin sensitivity, hormonal balance and ovarian function. Most women notice improvements in energy and mood within 2–4 weeks, with cycle and skin improvements typically seen by 8–12 weeks.*
Berberine layers in metabolic support: most people notice fewer cravings and steadier energy within the first few weeks, with broader support for healthy carbohydrate and fat metabolism building over 8–12 weeks.*
That’s why the Duo ships monthly — and why every subscription is backed by our 90-Day Love-It Guarantee.
Backed by Real Science
Both formulas are built on published research — a 12-week clinical study on the exact Inositol+ formula, and clinically studied branded ingredients in Berberine.
“84% of women reported positive results from taking Inositol+”
In a 12-week clinical study of the exact Optify Inositol+ formula, women reported more regular cycles, noticeably better skin, improved energy, sleep quality and mood, less menstrual pain and flow, and reduced food cravings.
Third-party tested
“The 40:1 ratio matches the body’s own”
Research on Myo-Inositol and D-Chiro Inositol shows the two forms work best together in a 40:1 ratio — the same ratio found naturally in plasma — supporting healthy insulin signaling, ovulation and hormone balance in women.
Randomized comparison of inositol ratios
“9.6x greater absorption, sustained over 24 hours”
A randomized pharmacokinetic study in healthy volunteers found 550mg of Berberine Phytosome achieved up to 9.6x greater peak plasma berberine levels than 500mg of standard berberine chloride, and stayed elevated over 24 hours.
Randomized crossover, healthy volunteers
“Improved metabolic markers in 60 days”
A randomized, placebo-controlled trial in 49 overweight adults found that Berberine Phytosome, taken for 60 days, reduced fasting glucose, insulin, total cholesterol, triglycerides and visceral fat, with no adverse events reported.
49 adults, 60 days
Berberine ingredient research was conducted at the dosages shown, on the branded ingredients — not on the finished Optify formula, and not in people with a diagnosed medical condition. Results will vary.*
Why Choose Us Over Other Supplements?
ify
Don’t Just Take Our Word
I have PCOS. I tried the alternatives that were prescribed but I did not like the side effects. This has helped tremendously with my insulin resistance.
I can’t imagine being without this berberine supplement. I take it every day, and it helps reduce my sweet cravings. It’s become an important part of my daily routine, and I’m very happy with it.
I’ve only been taking these for a month now for my PCOS symptoms and I’ve already noticed an improvement in mood, energy, hair growth, appetite etc.
An excellent addition to my wellness regimen, and I genuinely feel the difference in my metabolism. This sort of berberine is the best type due to the dual form of absorption. Highly recommended!
I’ve been struggling for 5 years to figure out what was going on and how I could help myself feel better. Every test came back fine. My OBGYN friend recommended I try these just because “it won’t hurt” and it ended up being the thing that helped.
I purchased this product because I have PCOS and my period has been irregular in the past. I was over 40 days late on my period, started taking it and I’m on day two and woke up to my period! So to say I’m pleased is an understatement.
Try the Duo Risk-Free for 90 Days!
We’re so confident you’ll love your results that every Metabolic Duo subscription comes with a full 90-day money-back guarantee — enough time to complete a full 12-week routine and feel the difference for yourself.
Family owned · Made in a GMP-certified U.S. facility
Your Questions Answered
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Research cited above describes a 12-week study of Optify Inositol+ and published studies on HimaBerb® Berberine HCl and Berberine Phytosome® at the dosages/durations noted. Results vary. Consult your doctor before use, especially if pregnant, nursing, trying to conceive or on medication (including for blood sugar or blood pressure). HimaBerb® and Berberine Phytosome® are trademarks of their respective owners.